[HTML][HTML] The recycling of ERGIC-53 in the early secretory pathway: ERGIC-53 carries a cytosolic endoplasmic reticulum-exit determinant interacting with COPII
F Kappeler, DRC Klopfenstein, M Foguet… - Journal of Biological …, 1997 - ASBMB
Further investigation of the targeting of the intracellular membrane lectin endoplasmic
reticulum (ER)-Golgi intermediate compartment-53 (ERGIC-53) by site-directed mutagenesis
revealed that its lumenal and transmembrane domains together confer ER retention. In
addition we show that the cytoplasmic domain is required for exit from the ER indicating that
ERGIC-53 carries an ER-exit determinant. Two phenylalanines at the C terminus are
essential for ER-exit. Thus, ERGIC-53 contains determinants for ER retention as well as …
reticulum (ER)-Golgi intermediate compartment-53 (ERGIC-53) by site-directed mutagenesis
revealed that its lumenal and transmembrane domains together confer ER retention. In
addition we show that the cytoplasmic domain is required for exit from the ER indicating that
ERGIC-53 carries an ER-exit determinant. Two phenylalanines at the C terminus are
essential for ER-exit. Thus, ERGIC-53 contains determinants for ER retention as well as …
