Protein expression of hypoxia-inducible factor-1 alpha and hepatocellular carcinoma: a systematic review with meta-analysis

S Cao, S Yang, C Wu, Y Wang, J Jiang, Z Lu - Clinics and research in …, 2014 - Elsevier
Purpose To investigate the relationship of protein expression of hypoxia-inducible factor-1
alpha (HIF-1α) with clinicopathological factors and prognosis of hepatocellular carcinoma
(HCC). Methods PubMed and Embase were searched from their inception through August
2013 for studies that reported the association between protein expression of HIF-1α and
HCC. Random effects meta-analyses were used to summarize the odds ratios (ORs) and
95% confidence intervals (CIs). Results Eight studies involving 851 patients with HCC were …