Triggering receptor expressed on myeloid cells-2 expression tracks with M2-like macrophage activity and disease severity in COPD
Background Cell and animal models show a key role for Triggering Receptor Expressed on
Myeloid Cells (TREM)-2 in chronic airway disease after viral infection, but comparable
evidence in humans still needs to be established. Methods Lung tissue samples were
obtained from lung transplant recipients with Global Initiative for Chronic Obstructive Lung
Disease (GOLD) stage IV COPD (n= 16), nontransplantable donor lung tissues (n= 7), and
resected lung tissues from patients at risk or with GOLD stage I through IV (n= 55) and were …
Myeloid Cells (TREM)-2 in chronic airway disease after viral infection, but comparable
evidence in humans still needs to be established. Methods Lung tissue samples were
obtained from lung transplant recipients with Global Initiative for Chronic Obstructive Lung
Disease (GOLD) stage IV COPD (n= 16), nontransplantable donor lung tissues (n= 7), and
resected lung tissues from patients at risk or with GOLD stage I through IV (n= 55) and were …