Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases
K Hirota, GL Semenza - Biochemical and biophysical research …, 2005 - Elsevier
K Hirota, GL Semenza
Biochemical and biophysical research communications, 2005•ElsevierHypoxia-inducible factor 1 (HIF-1) functions as a master regulator of oxygen homeostasis by
mediating a wide range of cellular and systemic adaptive physiological responses to
reduced oxygen availability. In this review, we will summarize recent progress in elucidating
the molecular mechanisms of HIF-1 activation, focusing on the role of oxygen-dependent
prolyl and asparaginyl hydroxylases in hypoxia signal transduction.
mediating a wide range of cellular and systemic adaptive physiological responses to
reduced oxygen availability. In this review, we will summarize recent progress in elucidating
the molecular mechanisms of HIF-1 activation, focusing on the role of oxygen-dependent
prolyl and asparaginyl hydroxylases in hypoxia signal transduction.
Hypoxia-inducible factor 1 (HIF-1) functions as a master regulator of oxygen homeostasis by mediating a wide range of cellular and systemic adaptive physiological responses to reduced oxygen availability. In this review, we will summarize recent progress in elucidating the molecular mechanisms of HIF-1 activation, focusing on the role of oxygen-dependent prolyl and asparaginyl hydroxylases in hypoxia signal transduction.
Elsevier
