The multifaceted relationship between IL-10 and adaptive immunity: putting together the pieces of a puzzle
S Mocellin, F Marincola, CR Rossi, D Nitti… - Cytokine & growth factor …, 2004 - Elsevier
Interleukin-10 (IL-10) is a pleiotropic cytokine that modulates the function of several adaptive
immunity-related cells. Although generally considered an immunosuppressive molecule, IL-
10 possesses immunostimulatory properties in several in vitro and in vivo models. These
very different outcomes are believed to depend upon experimental conditions, the dominant
immune effector mediating a given immune response, the timing of IL-10 production/
administration, and IL-10 dose and/or location of expression. In the present work, we review …
immunity-related cells. Although generally considered an immunosuppressive molecule, IL-
10 possesses immunostimulatory properties in several in vitro and in vivo models. These
very different outcomes are believed to depend upon experimental conditions, the dominant
immune effector mediating a given immune response, the timing of IL-10 production/
administration, and IL-10 dose and/or location of expression. In the present work, we review …
