The clinical utility of anti-double-stranded DNA antibodies and the challenges of their determination

E Mummert, MJ Fritzler, C Sjöwall, C Bentow… - Journal of …, 2018 - Elsevier
Autoantibodies against double-stranded DNA (dsDNA) were first described> 60 years ago
and although they are still one of the most clinically relevant autoantibodies, test results may
be more challenging to interpret compared to other autoantibody tests. They are a
serological hallmark of systemic lupus erythematosus (SLE) and are included in both the
American College of Rheumatology (ACR) and the Systemic Lupus International
Collaborating Clinics (SLICC) classification criteria for SLE. Furthermore, anti-dsDNA …