Inflammatory cells, microglia and MHC class II antigen-positive cells in the spinal cord of Lewis rats with acute and chronic relapsing experimental autoimmune …
PA McCombe, J De Jersey, MP Pender - Journal of neuroimmunology, 1994 - Elsevier
Chronic relapsing experimental autoimmune encephalomyelitis (CR-EAE) was induced in
Lewis rats by inoculation with guinea pig spinal cord and adjuvants and treatment with low
dose cyclosporin A (CsA). Acute EAE was induced by the same method without CsA
treatment. Immunocytochemistry and flow cytometry were used to assess inflammatory cells
and MHC class II (Ia) antigen expression in the central nervous system of these rats. The
inflammatory infiltrate was composed mainly of CD4+ T cells and macrophages, and αß T …
Lewis rats by inoculation with guinea pig spinal cord and adjuvants and treatment with low
dose cyclosporin A (CsA). Acute EAE was induced by the same method without CsA
treatment. Immunocytochemistry and flow cytometry were used to assess inflammatory cells
and MHC class II (Ia) antigen expression in the central nervous system of these rats. The
inflammatory infiltrate was composed mainly of CD4+ T cells and macrophages, and αß T …
