CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells.
FS Wong, I Visintin, L Wen, RA Flavell… - The Journal of …, 1996 - rupress.org
FS Wong, I Visintin, L Wen, RA Flavell, CA Janeway Jr
The Journal of experimental medicine, 1996•rupress.orgT cells play an important role in the pathogenesis of diabetes in the nonobese diabetic
(NOD) mouse. CD8 cytotoxic T cell lines and clones were generated from the lymphocytic
infiltrate in the islets of Langerhans of young (7-wk-old). NOD mice by growing them on
(NOD x B6-RIP-B7-1) F1 islets. These cells proliferate specifically to NOD islets and kill NOD
islets in vitro. The cells are restricted by H-2Kd, and all bear T cell antigen receptor encoded
by V beta 6. When these CD8 T cell lines and clones are adoptively transferred to irradiated …
(NOD) mouse. CD8 cytotoxic T cell lines and clones were generated from the lymphocytic
infiltrate in the islets of Langerhans of young (7-wk-old). NOD mice by growing them on
(NOD x B6-RIP-B7-1) F1 islets. These cells proliferate specifically to NOD islets and kill NOD
islets in vitro. The cells are restricted by H-2Kd, and all bear T cell antigen receptor encoded
by V beta 6. When these CD8 T cell lines and clones are adoptively transferred to irradiated …
T cells play an important role in the pathogenesis of diabetes in the nonobese diabetic (NOD) mouse. CD8 cytotoxic T cell lines and clones were generated from the lymphocytic infiltrate in the islets of Langerhans of young (7-wk-old). NOD mice by growing them on (NOD x B6-RIP-B7-1)F1 islets. These cells proliferate specifically to NOD islets and kill NOD islets in vitro. The cells are restricted by H-2Kd, and all bear T cell antigen receptor encoded by V beta 6. When these CD8 T cell lines and clones are adoptively transferred to irradiated female NOD, young NOD-SCID, and CB17-SCID mice, diabetes occurs very rapidly, within 10 d of transfer and without CD4 T cells.
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