CXCR3, CXCL10 and type 1 diabetes
A Antonelli, SM Ferrari, A Corrado, E Ferrannini… - Cytokine & growth factor …, 2014 - Elsevier
Abstract Type 1 diabetes (T1D) is due to antigen-specific assaults on the insulin producing
pancreatic β-cells by diabetogenic T-helper (Th) 1 cells.(CXC motif) ligand (CXCL) 10, an
interferon-γ inducible Th1 chemokine, and its receptor,(CXC motif) receptor (CXCR) 3, have
an important role in different autoimmune diseases. High circulating CXCL10 levels were
detected in new onset T1D patients, in association with a Th1 autoimmune response.
Furthermore β-cells produce CXCL10, under the influence of Th1 cytokines, that suppresses …
pancreatic β-cells by diabetogenic T-helper (Th) 1 cells.(CXC motif) ligand (CXCL) 10, an
interferon-γ inducible Th1 chemokine, and its receptor,(CXC motif) receptor (CXCR) 3, have
an important role in different autoimmune diseases. High circulating CXCL10 levels were
detected in new onset T1D patients, in association with a Th1 autoimmune response.
Furthermore β-cells produce CXCL10, under the influence of Th1 cytokines, that suppresses …
