[HTML][HTML] Gain-of-function R225Q mutation in AMP-activated protein kinase γ3 subunit increases mitochondrial biogenesis in glycolytic skeletal muscle
PM Garcia-Roves, ME Osler, MH Holmstrom… - Journal of Biological …, 2008 - ASBMB
AMP-activated protein kinase (AMPK) is a heterotrimeric complex, composed of a catalytic
subunit (α) and two regulatory subunits (β and γ), that works as a cellular energy sensor. The
existence of multiple heterotrimeric complexes provides a molecular basis for the multiple
roles of this highly conserved signaling system. The AMPK γ3 subunit is predominantly
expressed in skeletal muscle, mostly in type II glycolytic fiber types. We determined whether
the AMPK γ3 subunit has a role in signaling pathways that mediate mitochondrial …
subunit (α) and two regulatory subunits (β and γ), that works as a cellular energy sensor. The
existence of multiple heterotrimeric complexes provides a molecular basis for the multiple
roles of this highly conserved signaling system. The AMPK γ3 subunit is predominantly
expressed in skeletal muscle, mostly in type II glycolytic fiber types. We determined whether
the AMPK γ3 subunit has a role in signaling pathways that mediate mitochondrial …