[HTML][HTML] Gα12/13-mediated up-regulation of TRPC6 negatively regulates endothelin-1-induced cardiac myofibroblast formation and collagen synthesis through …
M Nishida, N Onohara, Y Sato, R Suda… - Journal of Biological …, 2007 - ASBMB
Sustained elevation of [Ca 2+] i has been implicated in many cellular events. We previously
reported that α subunits of G 12 family G proteins (Gα 12/13) participate in sustained Ca 2+
influx required for the activation of nuclear factor of activated T cells (NFAT), a Ca 2+-
responsive transcriptional factor, in rat neonatal cardiac fibroblasts. Here, we demonstrate
that Gα 12/13-mediated up-regulation of canonical transient receptor potential 6 (TRPC6)
channels participates in sustained Ca 2+ influx and NFAT activation by endothelin (ET)-1 …
reported that α subunits of G 12 family G proteins (Gα 12/13) participate in sustained Ca 2+
influx required for the activation of nuclear factor of activated T cells (NFAT), a Ca 2+-
responsive transcriptional factor, in rat neonatal cardiac fibroblasts. Here, we demonstrate
that Gα 12/13-mediated up-regulation of canonical transient receptor potential 6 (TRPC6)
channels participates in sustained Ca 2+ influx and NFAT activation by endothelin (ET)-1 …