WNT1 inducible signaling pathway protein 1 (WISP1): a novel mediator linking development and disease

B Berschneider, M Königshoff - The international journal of biochemistry & …, 2011 - Elsevier
B Berschneider, M Königshoff
The international journal of biochemistry & cell biology, 2011Elsevier
WISP1 is a secreted, matricellular protein allocated to the CCN protein family. The CCN
protein family consists of six, modular structured, secreted proteins. WISP1 is mainly
expressed during organ development and under diseased conditions, such as fibrosis or
cancer. Its expression is associated with proliferation, cytoprotection, as well as extracellular
matrix production, thereby representing a highly attractive therapeutical target for future
applications.
WISP1 is a secreted, matricellular protein allocated to the CCN protein family. The CCN protein family consists of six, modular structured, secreted proteins. WISP1 is mainly expressed during organ development and under diseased conditions, such as fibrosis or cancer. Its expression is associated with proliferation, cytoprotection, as well as extracellular matrix production, thereby representing a highly attractive therapeutical target for future applications.
Elsevier