Treatment of essential hypertension with chlorothiazide (Diuril): its use alone and combined with other antihypertensive agents

ED Freis, A Wanko, IM Wilson… - Journal of the American …, 1958 - jamanetwork.com
Ten hypertensive patients were hospitalized on a constant intake of sodium chloride until
their blood pressure levels had stabilized. Chlorothiazide in amounts of 1.5 Gm. per day
reduced the systolic blood pressure in all. The average reduction was 18.7%, it took place
within two or three days and was maintained to the end of a six-day period of medication.
When it was withdrawn the blood pressure returned to its former level. Chlorothiazide
(maintenance dose, 0.5 Gm. twice daily) added to the regimen of 73 ambulatory …