[HTML][HTML] Essential role of β-catenin in postnatal bone acquisition

SL Holmen, CR Zylstra, A Mukherjee, RE Sigler… - Journal of Biological …, 2005 - ASBMB
Mutations in the Wnt co-receptor LRP5 alter bone mass in humans, but the mechanisms
responsible for Wnts actions in bone are unclear. To investigate the role of the classical Wnt
signaling pathway in osteogenesis, we generated mice lacking the β-catenin or
adenomatous polyposis coli (Apc) genes in osteoblasts. Loss of β-catenin produced severe
osteopenia with striking increases in osteoclasts, whereas constitutive activation of β-catenin
in the conditional Apc mutants resulted in dramatically increased bone deposition and a …