Pharmacologic ER stress induces non-alcoholic steatohepatitis in an animal model

JS Lee, Z Zheng, R Mendez, SW Ha, Y Xie, K Zhang - Toxicology letters, 2012 - Elsevier
Endoplasmic reticulum (ER) stress refers to a condition of accumulation of unfolded or
misfolded proteins in the ER lumen, which is known to activate an intracellular stress
signaling termed Unfolded Protein Response (UPR). A number of pharmacologic reagents
or pathophysiologic stimuli can induce ER stress and activation of the UPR signaling,
leading to alteration of cell physiology that is associated with the initiation and progression
of a variety of diseases. Non-alcoholic steatohepatitis (NASH), characterized by hepatic …