[HTML][HTML] Identification of native atrial G-protein-regulated inwardly rectifying K+ (GIRK4) channel homomultimers

S Corey, DE Clapham - Journal of Biological Chemistry, 1998 - ASBMB
G-protein-regulated inwardly rectifying K+(GIRK) channels play critical inhibitory roles
throughout the nervous system, heart, and pancreas. They are believed to be
heterotetramers consisting of GIRK1 (Kir3. 1) and either GIRK2 (Kir3. 2), GIRK3 (Kir3. 3), or
GIRK4 (Kir3. 4) subunits. The GIRK1 subunit is hypothesized to be critical to form GIRK
channels with normal channel kinetics based on heterologous expression studies. However,
GIRK2 and GIRK3 proteins are present in areas of the brain where no GIRK1 has been …