Leukaemia stem cells and the evolution of cancer-stem-cell research

BJP Huntly, DG Gilliland - Nature Reviews Cancer, 2005 - nature.com
BJP Huntly, DG Gilliland
Nature Reviews Cancer, 2005nature.com
Many cancers seem to depend on a small population of'cancer stem cells' for their continued
growth and propagation. The leukaemia stem cell (LSC) was the first such cell to be
described. The origins of these cells are controversial, and their biology—like that of their
normal-tissue counterpart, the haematopoietic stem cell (HSC)—is still not fully elucidated.
However, the LSC is likely to be the most crucial target in the treatment of leukaemias, and a
thorough understanding of its biology—particularly of how the LSC differs from the HSC …
Abstract
Many cancers seem to depend on a small population of 'cancer stem cells' for their continued growth and propagation. The leukaemia stem cell (LSC) was the first such cell to be described. The origins of these cells are controversial, and their biology — like that of their normal-tissue counterpart, the haematopoietic stem cell (HSC) — is still not fully elucidated. However, the LSC is likely to be the most crucial target in the treatment of leukaemias, and a thorough understanding of its biology — particularly of how the LSC differs from the HSC — might allow it to be selectively targeted, improving therapeutic outcome.
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