Co-stimulatory members of the TNFR family: keys to effective T-cell immunity?

M Croft - Nature Reviews Immunology, 2003 - nature.com
M Croft
Nature Reviews Immunology, 2003nature.com
Interactions between co-stimulatory ligands and their receptors are crucial for the activation
of T cells, the prevention of tolerance and the development of T-cell immunity. It is now
evident that members of the immunoglobulin-like CD28–B7 co-stimulatory family cannot fully
account for an effective long-lasting T-cell response or the generation of memory T cells.
Several members of the tumour-necrosis factor receptor (TNFR) superfamily—OX40, 4-1BB,
CD27, CD30 and HVEM (herpes-virus entry mediator)—are poised to deliver co-stimulatory …
Abstract
Interactions between co-stimulatory ligands and their receptors are crucial for the activation of T cells, the prevention of tolerance and the development of T-cell immunity. It is now evident that members of the immunoglobulin-like CD28–B7 co-stimulatory family cannot fully account for an effective long-lasting T-cell response or the generation of memory T cells. Several members of the tumour-necrosis factor receptor (TNFR) superfamily — OX40, 4-1BB, CD27, CD30 and HVEM (herpes-virus entry mediator) — are poised to deliver co-stimulatory signals both early and late after encounter with antigen. The roles of these molecules in initiating and sustaining the T-cell response and in promoting long-lived immunity are discussed.
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