[HTML][HTML] Roles of caspases in necrotic cell death

J Yuan, A Najafov, BF Py - Cell, 2016 - cell.com
Cell, 2016cell.com
Caspases were originally identified as important mediators of inflammatory response and
apoptosis. Recent discoveries, however, have unveiled their roles in mediating and
suppressing two regulated forms of necrotic cell death, termed pyroptosis and necroptosis,
respectively. These recent advances have significantly expanded our understanding of the
roles of caspases in regulating development, adult homeostasis, and host defense
response.
Caspases were originally identified as important mediators of inflammatory response and apoptosis. Recent discoveries, however, have unveiled their roles in mediating and suppressing two regulated forms of necrotic cell death, termed pyroptosis and necroptosis, respectively. These recent advances have significantly expanded our understanding of the roles of caspases in regulating development, adult homeostasis, and host defense response.
cell.com