[HTML][HTML] Mitochondrial C1-tetrahydrofolate synthase (MTHFD1L) supports the flow of mitochondrial one-carbon units into the methyl cycle in embryos

ST Pike, R Rajendra, K Artzt, DR Appling - Journal of Biological Chemistry, 2010 - ASBMB
Mitochondrial folate-dependent one-carbon (1-C) metabolism converts 1-C donors such as
serine and glycine to formate, which is exported and incorporated into the cytoplasmic
tetrahydrofolate (THF) 1-C pool. Developing embryos depend on this mitochondrial pathway
to provide 1-C units for cytoplasmic process such as de novo purine biosynthesis and the
methyl cycle. This pathway is composed of sequential methylene-THF dehydrogenase,
methenyl-THF cyclohydrolase, and 10-formyl-THF synthetase activities. In embryonic …