Immune evasion of tumor cells using membrane-bound complement regulatory proteins
A Gorter, S Meri - Immunology today, 1999 - cell.com
A Gorter, S Meri
Immunology today, 1999•cell.comMembrane-bound complement regulatory proteins (mCRPs) play an important role in the
protection of cells from complement-mediated injury. It is now apparent that malignant tumor
cells also express these proteins to escape complement attack. Here, Arko Gorter and
Seppo Meri discuss the implications of complement resistance for the immunotherapeutic
treatment of solid tumors with monoclonal antibodies.
protection of cells from complement-mediated injury. It is now apparent that malignant tumor
cells also express these proteins to escape complement attack. Here, Arko Gorter and
Seppo Meri discuss the implications of complement resistance for the immunotherapeutic
treatment of solid tumors with monoclonal antibodies.
Abstract
Membrane-bound complement regulatory proteins (mCRPs) play an important role in the protection of cells from complement-mediated injury. It is now apparent that malignant tumor cells also express these proteins to escape complement attack. Here, Arko Gorter and Seppo Meri discuss the implications of complement resistance for the immunotherapeutic treatment of solid tumors with monoclonal antibodies.
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