[PDF][PDF] Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma
Neuron, 2007•cell.com
Recent studies have identified stem cells in brain cancer. However, their relationship to
normal CNS progenitors, including dependence on common lineage-restricted pathways, is
unclear. We observe expression of the CNS-restricted transcription factor, OLIG2, in human
glioma stem and progenitor cells reminiscent of type C transit-amplifying cells in germinal
zones of the adult brain. Olig2 function is required for proliferation of neural progenitors and
for glioma formation in a genetically relevant murine model. Moreover, we show p21 …
normal CNS progenitors, including dependence on common lineage-restricted pathways, is
unclear. We observe expression of the CNS-restricted transcription factor, OLIG2, in human
glioma stem and progenitor cells reminiscent of type C transit-amplifying cells in germinal
zones of the adult brain. Olig2 function is required for proliferation of neural progenitors and
for glioma formation in a genetically relevant murine model. Moreover, we show p21 …
Summary
Recent studies have identified stem cells in brain cancer. However, their relationship to normal CNS progenitors, including dependence on common lineage-restricted pathways, is unclear. We observe expression of the CNS-restricted transcription factor, OLIG2, in human glioma stem and progenitor cells reminiscent of type C transit-amplifying cells in germinal zones of the adult brain. Olig2 function is required for proliferation of neural progenitors and for glioma formation in a genetically relevant murine model. Moreover, we show p21WAF1/CIP1, a tumor suppressor and inhibitor of stem cell proliferation, is directly repressed by OLIG2 in neural progenitors and gliomas. Our findings identify an Olig2-regulated lineage-restricted pathway critical for proliferation of normal and tumorigenic CNS stem cells.
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