[HTML][HTML] T cell factor 4 is a pro-catabolic and apoptotic factor in human articular chondrocytes by potentiating nuclear factor κB signaling
T cell factor/lymphoid enhancer factor (TCF/LEF) transcription factors are downstream
effectors of Wnt/β-catenin signaling, which has been implicated in the development and
progression of osteoarthritis (OA). This study aimed to investigate the role of TCF/LEF
transcription factors in human articular chondrocytes. Primary human osteoarthritic cartilage
predominantly expressed TCF4 and to a lesser extent, LEF1 and TCF3 mRNA.
Overexpression of TCF4, but not of TCF3 or LEF1, induced MMP-1,-3, and-13 expression …
effectors of Wnt/β-catenin signaling, which has been implicated in the development and
progression of osteoarthritis (OA). This study aimed to investigate the role of TCF/LEF
transcription factors in human articular chondrocytes. Primary human osteoarthritic cartilage
predominantly expressed TCF4 and to a lesser extent, LEF1 and TCF3 mRNA.
Overexpression of TCF4, but not of TCF3 or LEF1, induced MMP-1,-3, and-13 expression …