[HTML][HTML] Roles of β-catenin signaling in phenotypic expression and proliferation of articular cartilage superficial zone cells
R Yasuhara, Y Ohta, T Yuasa, N Kondo, T Hoang… - Laboratory …, 2011 - Elsevier
The superficial zone (SFZ) of articular cartilage has unique structural and biomechanical
features, is thought to promote self-renewal of articular cartilage, and is thus important for
joint long-term function, but the mechanisms regulating its properties remain unclear.
Previous studies revealed that Wnt/β-catenin signaling is continuously active in SFZ,
indicating that it may be essential for SFZ function. Thus, we examined whether Wnt/β-
catenin signaling regulates proliferation and phenotypic expression in SFZ cells. Using …
features, is thought to promote self-renewal of articular cartilage, and is thus important for
joint long-term function, but the mechanisms regulating its properties remain unclear.
Previous studies revealed that Wnt/β-catenin signaling is continuously active in SFZ,
indicating that it may be essential for SFZ function. Thus, we examined whether Wnt/β-
catenin signaling regulates proliferation and phenotypic expression in SFZ cells. Using …