Bicarbonate supplementation slows progression of CKD and improves nutritional status
I de Brito-Ashurst, M Varagunam… - Journal of the …, 2009 - journals.lww.com
Bicarbonate supplementation preserves renal function in experimental chronic kidney
disease (CKD), but whether the same benefit occurs in humans is unknown. Here, we
randomly assigned 134 adult patients with CKD (creatinine clearance [CrCl] 15 to 30 ml/min
per 1.73 m 2) and serum bicarbonate 16 to 20 mmol/L to either supplementation with oral
sodium bicarbonate or standard care for 2 yr. The primary end points were rate of CrCl
decline, the proportion of patients with rapid decline of CrCl (> 3 ml/min per 1.73 m 2/yr), and …
disease (CKD), but whether the same benefit occurs in humans is unknown. Here, we
randomly assigned 134 adult patients with CKD (creatinine clearance [CrCl] 15 to 30 ml/min
per 1.73 m 2) and serum bicarbonate 16 to 20 mmol/L to either supplementation with oral
sodium bicarbonate or standard care for 2 yr. The primary end points were rate of CrCl
decline, the proportion of patients with rapid decline of CrCl (> 3 ml/min per 1.73 m 2/yr), and …