[HTML][HTML] Phosphorylation of ribosomal protein S6 Is inhibitory for autophagy in isolated rat hepatocytes (∗)
EFC Blommaart, JJFP Luiken, PJE Blommaart… - Journal of Biological …, 1995 - ASBMB
In rat hepatocytes, autophagy is known to be inhibited by amino acids. Insulin and cell
swelling promote inhibition by amino acids. Each of the conditions leading to inhibition of
autophagic proteolysis was found to be associated with phosphorylation of a 31-kDa protein
that we identified as ribosomal protein S6. A combination of leucine, tyrosine, and
phenylalanine, which efficiently inhibits autophagic proteolysis, was particularly effective in
stimulating S6 phosphorylation. The relationship between the percentage inhibition of …
swelling promote inhibition by amino acids. Each of the conditions leading to inhibition of
autophagic proteolysis was found to be associated with phosphorylation of a 31-kDa protein
that we identified as ribosomal protein S6. A combination of leucine, tyrosine, and
phenylalanine, which efficiently inhibits autophagic proteolysis, was particularly effective in
stimulating S6 phosphorylation. The relationship between the percentage inhibition of …