[HTML][HTML] Myocardial ischemia activates an injurious innate immune signaling via cardiac heat shock protein 60 and Toll-like receptor 4
Innate immune response after transient ischemia is the most common cause of myocardial
inflammation and may contribute to injury, yet the detailed signaling mechanisms leading to
such a response are not well understood. Herein we tested the hypothesis that myocardial
ischemia activates interleukin receptor-associated kinase-1 (IRAK-1), a kinase critical for the
innate immune signaling such as that of Toll-like receptors (TLRs), via a mechanism that
involves heat shock proteins (HSPs) and TLRs. Coronary artery occlusion induced a rapid …
inflammation and may contribute to injury, yet the detailed signaling mechanisms leading to
such a response are not well understood. Herein we tested the hypothesis that myocardial
ischemia activates interleukin receptor-associated kinase-1 (IRAK-1), a kinase critical for the
innate immune signaling such as that of Toll-like receptors (TLRs), via a mechanism that
involves heat shock proteins (HSPs) and TLRs. Coronary artery occlusion induced a rapid …