Regulation of cell death: the calcium–apoptosis link
S Orrenius, B Zhivotovsky, P Nicotera - Nature reviews Molecular cell …, 2003 - nature.com
S Orrenius, B Zhivotovsky, P Nicotera
Nature reviews Molecular cell biology, 2003•nature.comTo live or to die? This crucial question eloquently reflects the dual role of Ca2+ in living
organisms–survival factor or ruthless killer. It has long been known that Ca2+ signals govern
a host of vital cell functions and so are necessary for cell survival. However, more recently it
has become clear that cellular Ca2+ overload, or perturbation of intracellular Ca2+
compartmentalization, can cause cytotoxicity and trigger either apoptotic or necrotic cell
death.
organisms–survival factor or ruthless killer. It has long been known that Ca2+ signals govern
a host of vital cell functions and so are necessary for cell survival. However, more recently it
has become clear that cellular Ca2+ overload, or perturbation of intracellular Ca2+
compartmentalization, can cause cytotoxicity and trigger either apoptotic or necrotic cell
death.
Abstract
To live or to die? This crucial question eloquently reflects the dual role of Ca2+ in living organisms – survival factor or ruthless killer. It has long been known that Ca2+ signals govern a host of vital cell functions and so are necessary for cell survival. However, more recently it has become clear that cellular Ca2+ overload, or perturbation of intracellular Ca2+ compartmentalization, can cause cytotoxicity and trigger either apoptotic or necrotic cell death.
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