[HTML][HTML] Molecular cloning and characterization of endosialin, a C-type lectin-like cell surface receptor of tumor endothelium
S Christian, H Ahorn, A Koehler, F Eisenhaber… - Journal of Biological …, 2001 - ASBMB
Endosialin, the antigen identified with monoclonal antibody FB5, is a highly restricted 165-
kDa cell surface glycoprotein expressed by tumor blood vessel endothelium in a broad
range of human cancers but not detected in blood vessels or other cell types in many normal
tissues. Functional analysis of endosialin has been hampered by a lack of information about
its molecular structure. In this study, we describe the purification and partial amino acid
sequencing of endosialin, leading to the cloning of a full-length cDNA with an open reading …
kDa cell surface glycoprotein expressed by tumor blood vessel endothelium in a broad
range of human cancers but not detected in blood vessels or other cell types in many normal
tissues. Functional analysis of endosialin has been hampered by a lack of information about
its molecular structure. In this study, we describe the purification and partial amino acid
sequencing of endosialin, leading to the cloning of a full-length cDNA with an open reading …