The antivascular action of physiotherapy ultrasound on a murine tumor: role of a microbubble contrast agent
AKW Wood, RM Bunte, JD Cohen, JH Tsai… - Ultrasound in medicine …, 2007 - Elsevier
This study investigated whether a microbubble-containing ultrasound contrast agent had a
role in the antivascular action of physiotherapy ultrasound on tumor neovasculature.
Ultrasound images (B-mode and contrast-enhanced power Doppler [0.02 mL Definity]) were
made of 22 murine melanomas (K173522). The tumor was insonated (ISATA= 1.7 W cm–2,
1 MHz, continuous output) for 3 min and the power Doppler observations of the pre-and
postinsonation tumor vascularities were analyzed. Significant reductions (p= 0.005 for …
role in the antivascular action of physiotherapy ultrasound on tumor neovasculature.
Ultrasound images (B-mode and contrast-enhanced power Doppler [0.02 mL Definity]) were
made of 22 murine melanomas (K173522). The tumor was insonated (ISATA= 1.7 W cm–2,
1 MHz, continuous output) for 3 min and the power Doppler observations of the pre-and
postinsonation tumor vascularities were analyzed. Significant reductions (p= 0.005 for …