Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells
Z Chen, A Laurence, Y Kanno… - Proceedings of the …, 2006 - National Acad Sciences
Proceedings of the national academy of sciences, 2006•National Acad Sciences
Suppressor of cytokine signaling (Socs) 3 is a cytokine-inducible inhibitor with critical but
selective cell-specific effects. We show that deficiency of Socs3 in T cells had minimal effects
on differentiation of T cells to the T helper (Th) 1 or Th2 subsets; accordingly, Socs3 had no
effect on IL-12-dependent signal transducer and activator of transcription (Stat) 4
phosphorylation or IL-4-dependent Stat6 phosphorylation. By contrast, Socs3 was found to
be a major regulator of IL-23-mediated Stat3 phosphorylation and Th17 generation, and …
selective cell-specific effects. We show that deficiency of Socs3 in T cells had minimal effects
on differentiation of T cells to the T helper (Th) 1 or Th2 subsets; accordingly, Socs3 had no
effect on IL-12-dependent signal transducer and activator of transcription (Stat) 4
phosphorylation or IL-4-dependent Stat6 phosphorylation. By contrast, Socs3 was found to
be a major regulator of IL-23-mediated Stat3 phosphorylation and Th17 generation, and …
Suppressor of cytokine signaling (Socs) 3 is a cytokine-inducible inhibitor with critical but selective cell-specific effects. We show that deficiency of Socs3 in T cells had minimal effects on differentiation of T cells to the T helper (Th) 1 or Th2 subsets; accordingly, Socs3 had no effect on IL-12-dependent signal transducer and activator of transcription (Stat) 4 phosphorylation or IL-4-dependent Stat6 phosphorylation. By contrast, Socs3 was found to be a major regulator of IL-23-mediated Stat3 phosphorylation and Th17 generation, and Stat3 directly binds to the IL-17A and IL-17F promoters. We conclude that Socs3 is an essential negative regulator of IL-23 signaling, inhibition of which constrains the generation of Th17 differentiation.
National Acad Sciences