[HTML][HTML] Urokinase-type plasminogen activator receptor (uPAR)-mediated regulation of WNT/β-catenin signaling is enhanced in irradiated medulloblastoma cells
S Asuthkar, CS Gondi, AK Nalla, KK Velpula… - Journal of Biological …, 2012 - ASBMB
Urokinase plasminogen activator receptor (uPAR) is known to promote invasion, migration,
and metastasis in cancer cells. In this report, we showed that ionizing radiation (IR)-induced
uPAR has a role in WNT-β-catenin signaling and mediates induction of cancer stem cell
(CSC)-like properties in medulloblastoma cell lines UW228 and D283. We observed that IR
induced the expression of uPAR and CSC markers, such as Musashi-1 and CD44, and
activated WNT-7a-β-catenin signaling molecules. Overexpression of uPAR alone or with IR …
and metastasis in cancer cells. In this report, we showed that ionizing radiation (IR)-induced
uPAR has a role in WNT-β-catenin signaling and mediates induction of cancer stem cell
(CSC)-like properties in medulloblastoma cell lines UW228 and D283. We observed that IR
induced the expression of uPAR and CSC markers, such as Musashi-1 and CD44, and
activated WNT-7a-β-catenin signaling molecules. Overexpression of uPAR alone or with IR …