[HTML][HTML] Memory T-cell predominance following T-cell depletional therapy derives from homeostatic expansion of naive T cells
A Sener, AL Tang, DL Farber - American Journal of Transplantation, 2009 - Elsevier
T-cell depletion reportedly leads to alterations in the T-cell compartment with predominant
survival of memory phenotype CD4 T cells. Here, we asked whether the prevalence of
memory T cells postdepletion results from their inherent resistance to depletion and/or to the
homeostatic expansion of naive T cells and their phenotypic conversion to memory, which is
known to occur in lymphopenic conditions. Using a 'mosaic memory'mouse model with
trackable populations of alloreactive memory T cells, we found that treatment with murine …
survival of memory phenotype CD4 T cells. Here, we asked whether the prevalence of
memory T cells postdepletion results from their inherent resistance to depletion and/or to the
homeostatic expansion of naive T cells and their phenotypic conversion to memory, which is
known to occur in lymphopenic conditions. Using a 'mosaic memory'mouse model with
trackable populations of alloreactive memory T cells, we found that treatment with murine …