The sweet and sour of cancer: glycans as novel therapeutic targets
A growing body of evidence supports crucial roles for glycans at various pathophysiological
steps of tumour progression. Glycans regulate tumour proliferation, invasion,
haematogenous metastasis and angiogenesis, and increased understanding of these roles
sets the stage for developing pharmaceutical agents that target these molecules. Such novel
agents might be used alone or in combination with operative and/or chemoradiation
strategies for treating cancer.
steps of tumour progression. Glycans regulate tumour proliferation, invasion,
haematogenous metastasis and angiogenesis, and increased understanding of these roles
sets the stage for developing pharmaceutical agents that target these molecules. Such novel
agents might be used alone or in combination with operative and/or chemoradiation
strategies for treating cancer.
Abstract
A growing body of evidence supports crucial roles for glycans at various pathophysiological steps of tumour progression. Glycans regulate tumour proliferation, invasion, haematogenous metastasis and angiogenesis, and increased understanding of these roles sets the stage for developing pharmaceutical agents that target these molecules. Such novel agents might be used alone or in combination with operative and/or chemoradiation strategies for treating cancer.
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