Stressed out mitochondria: the role of mitochondria in ageing and cancer focussing on strategies and opportunities in human skin
AS Tulah, MA Birch-Machin - Mitochondrion, 2013 - Elsevier
Mitochondrial DNA damage has been used as a successful and unique biomarker of tissue
stress. A valuable example of this is sun damage in human skin which leads to ageing and
skin cancer. The skin is constantly exposed to the harmful effects of sunlight, such as
ultraviolet radiation, which causes it to age with observable characteristic features as well as
clinical precancerous lesions and skin cancer. Formation of free radicals by the sun's
harmful rays which contribute to oxidative stress has been linked to the induction of …
stress. A valuable example of this is sun damage in human skin which leads to ageing and
skin cancer. The skin is constantly exposed to the harmful effects of sunlight, such as
ultraviolet radiation, which causes it to age with observable characteristic features as well as
clinical precancerous lesions and skin cancer. Formation of free radicals by the sun's
harmful rays which contribute to oxidative stress has been linked to the induction of …