Prostatic adenocarcinoma is the most common cancer diagnosed in men and is often
multifocal. Ongoing controversy exists about the most appropriate system of tumor
classification and grading and the optimal curative treatment approaches. This review
examines recent progress in the pathogenesis of multifocal prostatic adenocarcinoma and
its biologic, pathologic, prognostic, and therapeutic implications. Prostatic cancer
multifocality makes accurate clinical staging difficult, and repeated revisions have been …