[HTML][HTML] Caspase-6 role in apoptosis of human neurons, amyloidogenesis, and Alzheimer's disease
A LeBlanc, H Liu, C Goodyer, C Bergeron… - Journal of Biological …, 1999 - ASBMB
Neuronal cell death, neurofibrillary tangles, and amyloid β peptide (Aβ) deposition depict
Alzheimer's disease (AD) pathology, but neuronal loss correlates best with dementia. We
have shown that increased production of Aβ is a consequence of neuronal apoptosis,
suggesting that apoptosis activates proteases involved in amyloid precursor protein (APP)
processing. Here, we investigate key effectors of cell death, caspases, in human neuronal
apoptosis and APP processing. We find that caspase-6 is activated and responsible for …
Alzheimer's disease (AD) pathology, but neuronal loss correlates best with dementia. We
have shown that increased production of Aβ is a consequence of neuronal apoptosis,
suggesting that apoptosis activates proteases involved in amyloid precursor protein (APP)
processing. Here, we investigate key effectors of cell death, caspases, in human neuronal
apoptosis and APP processing. We find that caspase-6 is activated and responsible for …
