Burn induces a Th-17 inflammatory response at the injury site
JR Sasaki, Q Zhang, MG Schwacha - Burns, 2011 - Elsevier
INTRODUCTION: The high incidence of morbidity and mortality following major burn can be
in part attributed to immune dysfunction and wound healing complications. Inflammation
plays a major role in the complex process of wound repair. Recently, a novel class of T-
helper cells, termed Th-17 cells, has been found to secrete the pro-inflammatory cytokines IL-
17 and IL-22. The Th-17 response also involves other cytokines, such as IL-6 and TGF-β,
which have been shown to be associated with burn-induced inflammation. Nonetheless, the …
in part attributed to immune dysfunction and wound healing complications. Inflammation
plays a major role in the complex process of wound repair. Recently, a novel class of T-
helper cells, termed Th-17 cells, has been found to secrete the pro-inflammatory cytokines IL-
17 and IL-22. The Th-17 response also involves other cytokines, such as IL-6 and TGF-β,
which have been shown to be associated with burn-induced inflammation. Nonetheless, the …