[HTML][HTML] Evidence for a partially folded intermediate in α-synuclein fibril formation
VN Uversky, J Li, AL Fink - Journal of Biological Chemistry, 2001 - ASBMB
Intracellular proteinaceous aggregates (Lewy bodies and Lewy neurites) of α-synuclein are
hallmarks of neurodegenerative diseases such as Parkinson's disease, dementia with Lewy
bodies, and multiple systemic atrophy. However, the molecular mechanisms underlying α-
synuclein aggregation into such filamentous inclusions remain unknown. An intriguing
aspect of this problem is that α-synuclein is a natively unfolded protein, with little or no
ordered structure under physiological conditions. This raises the question of how an …
hallmarks of neurodegenerative diseases such as Parkinson's disease, dementia with Lewy
bodies, and multiple systemic atrophy. However, the molecular mechanisms underlying α-
synuclein aggregation into such filamentous inclusions remain unknown. An intriguing
aspect of this problem is that α-synuclein is a natively unfolded protein, with little or no
ordered structure under physiological conditions. This raises the question of how an …