[HTML][HTML] Structure of the blood–brain barrier and its role in the transport of amino acids
RA Hawkins, RL O'Kane, IA Simpson, JR Vina - The Journal of nutrition, 2006 - Elsevier
Brain capillary endothelial cells form the blood–brain barrier (BBB). They are connected by
extensive tight junctions, and are polarized into luminal (blood-facing) and abluminal (brain-
facing) plasma membrane domains. The polar distribution of transport proteins mediates
amino acid (AA) homeostasis in the brain. The existence of two facilitative transporters for
neutral amino acids (NAAs) on both membranes provides the brain access to essential AAs.
Four Na+-dependent transporters of NAA exist in the abluminal membranes of the BBB …
extensive tight junctions, and are polarized into luminal (blood-facing) and abluminal (brain-
facing) plasma membrane domains. The polar distribution of transport proteins mediates
amino acid (AA) homeostasis in the brain. The existence of two facilitative transporters for
neutral amino acids (NAAs) on both membranes provides the brain access to essential AAs.
Four Na+-dependent transporters of NAA exist in the abluminal membranes of the BBB …
