The natural history of hepatitis C virus infection: host, viral, and environmental factors
DL Thomas, J Astemborski, RM Rai, FA Anania… - Jama, 2000 - jamanetwork.com
ContextHepatitis C virus (HCV) infection may resolve (viral clearance), persist without
complications, or cause end-stage liver disease (ESLD). The frequency and determinants of
these outcomes are poorly understood. ObjectiveTo assess the incidence and determinants
of viral clearance and ESLD among persons who acquired HCV infection from injection drug
use. Design and SettingCommunity-based prospective cohort study with enrollment in 1988-
1989 and a median follow-up of 8.8 years. SubjectsA total of 1667 persons aged 17 years or …
complications, or cause end-stage liver disease (ESLD). The frequency and determinants of
these outcomes are poorly understood. ObjectiveTo assess the incidence and determinants
of viral clearance and ESLD among persons who acquired HCV infection from injection drug
use. Design and SettingCommunity-based prospective cohort study with enrollment in 1988-
1989 and a median follow-up of 8.8 years. SubjectsA total of 1667 persons aged 17 years or …
