There is growing evidence that tyrosine phosphatases display an intrinsic enzymatic
preference for the sequence context flanking the target phosphotyrosines. On the other
hand, substrate selection in vivo is decisively guided by the enzyme-substrate connectivity in
the protein interaction network. We describe here a system wide strategy to infer
physiological substrates of protein-tyrosine phosphatases. Here we integrate, by a Bayesian
model, proteome wide evidence about in vitro substrate preference, as determined by a …