Improved chimaeric mouse model confirms that resident peritoneal macrophages are derived solely from bone marrow precursors
AR Murch, MD Grounds… - The Journal of …, 1984 - Wiley Online Library
AR Murch, MD Grounds, JM Papadimitriou
The Journal of Pathology, 1984•Wiley Online LibraryThe origin of resident peritoneal macrophages was studied in radiation mouse chimaeras
with and without reconstitution of the peritoneum with viable isogeneic peritoneal cells. The
selection of host and donor strains were such that the isoenzymes of glucose‐6‐phosphate
isomerase could be used to distinguish host from donor bone marrow derived cells. It was
found that the resident peritoneal macrophages were completely replaced by bone marrow
donor derived cells within 5–6 weeks. There was little difference between the results from …
with and without reconstitution of the peritoneum with viable isogeneic peritoneal cells. The
selection of host and donor strains were such that the isoenzymes of glucose‐6‐phosphate
isomerase could be used to distinguish host from donor bone marrow derived cells. It was
found that the resident peritoneal macrophages were completely replaced by bone marrow
donor derived cells within 5–6 weeks. There was little difference between the results from …
Abstract
The origin of resident peritoneal macrophages was studied in radiation mouse chimaeras with and without reconstitution of the peritoneum with viable isogeneic peritoneal cells. The selection of host and donor strains were such that the isoenzymes of glucose‐6‐phosphate isomerase could be used to distinguish host from donor bone marrow derived cells. It was found that the resident peritoneal macrophages were completely replaced by bone marrow donor derived cells within 5–6 weeks. There was little difference between the results from mice which had been additionally reconstituted with peritoneal cells and those which were not.
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