Anti-TNF therapy using etanercept suppresses degenerative and inflammatory changes in skeletal muscle of older SJL/J mice
H Nemoto, S Konno, H Sugimoto, H Nakazora… - … and molecular pathology, 2011 - Elsevier
Limb-girdle muscular dystrophy 2B and Miyoshi myopathy are characterized by muscle fiber
necrosis caused by a defect in dysferlin and inflammatory changes. SJL/J mice are deficient
in dysferlin and display severe inflammatory changes, most notably the presence of
cytokines, which may be related to destruction of the sarcolemma. We tested the hypothesis
that tumor necrosis factor (TNF) contributes to myofibril necrosis. Administration of
etanercept, an agent that blocks TNF, resulted in dose-dependent reductions in …
necrosis caused by a defect in dysferlin and inflammatory changes. SJL/J mice are deficient
in dysferlin and display severe inflammatory changes, most notably the presence of
cytokines, which may be related to destruction of the sarcolemma. We tested the hypothesis
that tumor necrosis factor (TNF) contributes to myofibril necrosis. Administration of
etanercept, an agent that blocks TNF, resulted in dose-dependent reductions in …