Vaccinia virus-specific CD8+ T-cell responses target a group of epitopes without a strong immunodominance hierarchy in humans
M Terajima, L Orphin, AM Leporati, P Pazoles, J Cruz… - Human immunology, 2008 - Elsevier
Immunization with vaccinia virus (VACV) resulted in long-lasting protection against smallpox
and successful global eradication of the disease. VACV elicits strong cellular and humoral
immune responses. Although neutralizing antibody is essential for protection, cellular
immunity seems to be more important for recovery from infection in humans. We analyzed
the immunodominance hierarchy of 73 previously identified VACV human CD8+ T-cell
epitopes restricted by HLA-A1,-A2,-A3,-A24,-B7, or-B44 alleles or the alleles belonging to …
and successful global eradication of the disease. VACV elicits strong cellular and humoral
immune responses. Although neutralizing antibody is essential for protection, cellular
immunity seems to be more important for recovery from infection in humans. We analyzed
the immunodominance hierarchy of 73 previously identified VACV human CD8+ T-cell
epitopes restricted by HLA-A1,-A2,-A3,-A24,-B7, or-B44 alleles or the alleles belonging to …