Rosette-forming human lymphoid cell lines. I. Establishment and evidence for origin of thymus-derived lymphocytes
J Minowada, T Ohnuma… - Journal of the National …, 1972 - academic.oup.com
J Minowada, T Ohnuma, GE Moore
Journal of the National Cancer Institute, 1972•academic.oup.comFour permanent lymphoid cell lines designated as MOLT# 1, 2, 3, and 4 were established
from the peripheral blood of a patient with acute lymphoblastic leukemia. The cells
resembled relatively mature lymphocytes. Neither immunoglobulins nor Epstein-Barr virus
was detectable. No receptors for immunoglobulin or complement were present, but the cells
bound with red blood cells of sheep, pig, goat, and horse to form rosettes. These cell lines
probably represent a subpopulation of human lymphocytes related to thymus-derived …
from the peripheral blood of a patient with acute lymphoblastic leukemia. The cells
resembled relatively mature lymphocytes. Neither immunoglobulins nor Epstein-Barr virus
was detectable. No receptors for immunoglobulin or complement were present, but the cells
bound with red blood cells of sheep, pig, goat, and horse to form rosettes. These cell lines
probably represent a subpopulation of human lymphocytes related to thymus-derived …
Summary
Four permanent lymphoid cell lines designated as MOLT #1, 2, 3, and 4 were established from the peripheral blood of a patient with acute lymphoblastic leukemia. The cells resembled relatively mature lymphocytes. Neither immunoglobulins nor Epstein-Barr virus was detectable. No receptors for immunoglobulin or complement were present, but the cells bound with red blood cells of sheep, pig, goat, and horse to form rosettes. These cell lines probably represent a subpopulation of human lymphocytes related to thymus-derived lymphocytes.
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