[HTML][HTML] Activation of phosphatidylinositol 3-kinase through glycoprotein 130 induces protein kinase B and p70 S6 kinase phosphorylation in cardiac myocytes
H Oh, Y Fujio, K Kunisada, H Hirota, H Matsui… - Journal of Biological …, 1998 - ASBMB
Phosphatidylinositol (PI) 3-kinase is known to be activated by cytokine stimulation through
different types of receptors to transduce intracellular responses. We have previously
reported that leukemia inhibitory factor (LIF) induces the activation of Janus kinase signal
transducer and activator of transcription (JAK-STAT) and mitogen-activated protein (MAP)
kinase pathways through glycoprotein (gp) 130 in cardiac myocytes. However, whether PI 3-
kinase is involved in regulation of gp130 signaling and the activation mechanisms by which …
different types of receptors to transduce intracellular responses. We have previously
reported that leukemia inhibitory factor (LIF) induces the activation of Janus kinase signal
transducer and activator of transcription (JAK-STAT) and mitogen-activated protein (MAP)
kinase pathways through glycoprotein (gp) 130 in cardiac myocytes. However, whether PI 3-
kinase is involved in regulation of gp130 signaling and the activation mechanisms by which …
