[HTML][HTML] Rhinovirus-induced modulation of gene expression in bronchial epithelial cells from subjects with asthma
YA Bochkov, KM Hanson, S Keles… - Mucosal …, 2010 - Elsevier
Rhinovirus (RV) infections trigger asthma exacerbations. Genome-wide expression analysis
of RV1A-infected primary bronchial epithelial cells from normal and asthmatic donors was
performed to determine whether asthma is associated with a unique pattern of RV-induced
gene expression. Virus replication rates were similar in cells from normal and asthmatic
donors. Overall, RV downregulated 975 and upregulated 69 genes. Comparisons of
transcriptional profiles generated from microarrays and confirmed by quantitative reverse …
of RV1A-infected primary bronchial epithelial cells from normal and asthmatic donors was
performed to determine whether asthma is associated with a unique pattern of RV-induced
gene expression. Virus replication rates were similar in cells from normal and asthmatic
donors. Overall, RV downregulated 975 and upregulated 69 genes. Comparisons of
transcriptional profiles generated from microarrays and confirmed by quantitative reverse …
