[HTML][HTML] Hypoxia-inducible expression of a natural cis-antisense transcript inhibits endothelial nitric-oxide synthase
The destabilization of endothelial nitric-oxide synthase (eNOS) mRNA in hypoxic endothelial
cells may be important in the etiology of vascular diseases, such as pulmonary
hypertension. Recently, an overlapping antisense transcript to eNOS/NOS3 was implicated
in the post-transcriptional regulation of eNOS. We demonstrate here that expression of
sONE, also known as eNOS antisense (NOS3AS) or autophagy 9-like 2 (APG9L2), is
robustly induced by hypoxia or functional deficiency of von Hippel-Lindau protein. sONE is …
cells may be important in the etiology of vascular diseases, such as pulmonary
hypertension. Recently, an overlapping antisense transcript to eNOS/NOS3 was implicated
in the post-transcriptional regulation of eNOS. We demonstrate here that expression of
sONE, also known as eNOS antisense (NOS3AS) or autophagy 9-like 2 (APG9L2), is
robustly induced by hypoxia or functional deficiency of von Hippel-Lindau protein. sONE is …