[HTML][HTML] Identification of strain-specific variants of mouse Adamts13 gene encoding von Willebrand factor-cleaving protease
F Banno, K Kaminaka, K Soejima, K Kokame… - Journal of Biological …, 2004 - ASBMB
Human ADAMTS13 was recently identified as a gene encoding von Willebrand factor-
cleaving protease, hADAMTS13. Both congenital and acquired defects in this enzyme can
cause thrombotic thrombocytopenic purpura. hADAMTS13 consists of 1,427 amino acid
residues and is composed of multiple structural domains including thrombospondin type 1
motifs and CUB domains. To analyze the functional roles of these domains in vivo, we
determined the cDNA sequence of the mouse ortholog, mADAMTS13. Unexpectedly, two …
cleaving protease, hADAMTS13. Both congenital and acquired defects in this enzyme can
cause thrombotic thrombocytopenic purpura. hADAMTS13 consists of 1,427 amino acid
residues and is composed of multiple structural domains including thrombospondin type 1
motifs and CUB domains. To analyze the functional roles of these domains in vivo, we
determined the cDNA sequence of the mouse ortholog, mADAMTS13. Unexpectedly, two …